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Electrochemical biosensors: recommended definitions and classification

Abstract
…An electrochemical biosensor is a self-contained integrated device, which is capable of providing specific quantitative or semi-quantitative analytical information using a biological recognition element (biochemical receptor) which is retained in direct spatial contact with an electrochemical transduction element. Because of their ability to be repeatedly calibrated, we recommend that a biosensor should be clearly distinguished from a bioanalytical system, which requires additional processing steps, such as reagent addition…Biosensors may be classified according to the biological specificity-conferring mechanism or, alternatively, to the mode of physico-chemical signal transduction…Biosensors may be further classified according to the analytes or reactions that they monitor: direct monitoring of analyte concentration or of reactions producing or consuming such analytes…

Comments
A clear and frequently cited paper with a useful definition of a biosensor from the vantage point of chemical sensors. Differentiation is made between single and multiple use biosensors. Very useful overview of analyte/receptor pairs. Comments on construction, performance and limitations of biosensors and specifically on the selectivity and reliability of electrochemical biosensors.

Citation
Daniel R. Thévenot, Klara Toth, Richard A. Durst, George S. Wilson, “Electrochemical biosensors: recommended definitions and classification,” Biosensors and Bioelectronics, Vol. 16, Iss. 1-2, January 2001, p. 121-131

Expertise Level
Introductory-Intermediate

Professional Field
Bioelectronics

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