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Review of analytical figures of merit of sensors and biosensors in clinical applications

Abstract
…Health care appears to provide the best opportunity for sensor development. Among the wide range of different sensors and biosensors, electrochemical biosensors are the most common in the clinical field, due to their high sensitivity and selectivity, portability, rapid response time and low cost. This article provides an up-to-date overview of the analytical performance of sensors and biosensors in clinical applications by discussing recent improvements, particularly due to┬áthe impact of nanotechnology.

Comments
Discussion of problems with biosensors in clinical applications: poor biocompatibility between the available materials and the complex nature of the clinical samples can lead to undesirable phenomena (e.g. cross reactivity, inhibition of the detection method, and non-specific adsorption of unwanted species in the samples). This can affect the accuracy, the sensitivity and the life-span of the sensor. Important and easy to follow discussion of figures of merit: sensitivity (a small change in analyte concentration causes a large change in the response), selectivity (a method is selective when the response of the analyte can be differentiated from every other response), limit of detection, repeatability, and reproducibility. Discussion of these figures of merit in electrochemical, optical, and piezoelectric biosensors. Discussion of bionsensors for diabetes, cholesterol, neurotransmitters (glutamate) and cancer biomarkers. Three page overview table.

Citation
Celine I.L. Justino, Teresa A. Rocha-Santos, Armando C. Duarte, “Review of analytical figures of merit of sensors and biosensors in clinical applications,” TrAC Trends in Analytical Chemistry, Vol. 29, Iss. 10, November 2010, p. 1172-1183

Expertise Level
Advanced

Professional Field
Chemistry, Healthcare

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