Characteristics of a multisensor system for non invasive glucose monitoring with external validation and prospective evaluation

Abstract
The Multisensor Glucose Monitoring System (MGMS) features non invasive sensors for dielectric characterisation of the skin and underlying tissue in a wide frequency range…as well as optical characterisation. In this paper we describe the results of using an MGMS in a miniaturised housing with fully integrated sensors and battery. Six patients with Type I Diabetes Mellitus…wore a single Multisensor at the upper arm position and performed a total of 45 in-clinic study days with 7 study days per patient on average (min. 5 and max. 10). Glucose changes were induced either orally or by i.v. glucose administration and the blood glucose was measured routinely. Several prospective data evaluation routines were applied to evaluate the data…

Comments
Technical discussion and performance study of multisensor approach to non-invasive glucose monitoring.  Wearable (armband on skin) sensors in KHz, MHz and GHz range use dielectric capacitive fringing field sensing + accelerometer + sweat, optical, humidity, and temperature sensors. Output passed to a magnitude/phase detector. Optical (LED) for skin microcirculation. Measurements collected every 20 sec. Development of a global model to analyze the data. Statistical evaluation of different sensor module combinations. MHz dielectric together with temp. assessment proved most effective.

Citation
Andreas Caduff, Martin Mueller, Alexander Megej, Francois Dewarrat, Roland E. Suri, Jelena Klisic, Marc Donath, Pavel Zakharov, Dominik Schaub, Werner A. Stahel, Mark S. Talary, “Characteristics of a multisensor system for non invasive glucose monitoring with external validation and prospective evaluation,” Biosensors and Bioelectronics, Vol. 26, Iss. 9, 15 May 2011, p. 3794-3800

Expertise Level
Intermediate

Professional Field
Bioelectronics

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